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@PHDTHESIS{Krebs:991096,
      author       = {Krebs, Janina},
      othercontributors = {Neulen, Joseph and Jahnen-Dechent, Wilhelm},
      title        = {{D}ie {R}olle des {F}etuin-{B} im menschlichen
                      {F}ertilisationsprozess},
      school       = {Rheinisch-Westfälische Technische Hochschule Aachen},
      type         = {Dissertation},
      address      = {Aachen},
      publisher    = {RWTH Aachen University},
      reportid     = {RWTH-2024-07681},
      pages        = {1 Online-Ressource : Illustrationen},
      year         = {2024},
      note         = {Veröffentlicht auf dem Publikationsserver der RWTH Aachen
                      University; Dissertation, Rheinisch-Westfälische Technische
                      Hochschule Aachen, 2024},
      abstract     = {The thesis “The role of Fetuin-B in the process of human
                      fertilization”, written by Janina Krebs, examines the
                      influence of Fetuin-B on the fertilization. The thesis
                      investigates the association between Fetuin-B and
                      fertilization rates (number of fertilized eggs) during an
                      ART-Therapy (assisted reproductive technology). More
                      precisely, the author analyses Fetuin-B’s ability to act
                      as a biological prognostic marker. An additional research
                      question of the thesis is, if Fetuin-B is influenced by
                      characteristics such as age, body-mass-index (BMI), nicotine
                      consumption, primary or secondary infertility. Therefore,
                      Fetuin-B levels were measured multiple times from 101
                      patients that underwent ART-therapy for the first time.
                      ELISA-technique was used for subsequent analysis. The main
                      result is that Fetuin-B significantly increases during
                      successful fertilization (fertilization rate $>25\%),$
                      whereas Fetuin-B does not increase during unsuccessful
                      fertilization (fertilization rate $<25\%).$ A previous pilot
                      study came to a same result, so these results confirm
                      previous pilot studies and provides further evidence that
                      Fetuin-B can act as a biological prognostic marker for
                      fertilization rates. In addition, this study finds that
                      Fetuin-B is not significantly influenced by individual
                      characteristics. Drawing the conclusion, we observed a
                      significantly increase of Fetuin-B during a successful
                      fertilization (fertilization rate $>25\%)$ which underlines
                      the essential importance of Fetuin-B during the
                      fertilization. In future, it would be interesting to examine
                      the promotor of gene regulation of Fetuin-B and to analyse
                      if there are more association partners of Fetuin-B.},
      cin          = {537100-2 ; 938420},
      ddc          = {610},
      cid          = {$I:(DE-82)537100-2_20140620$},
      typ          = {PUB:(DE-HGF)11},
      doi          = {10.18154/RWTH-2024-07681},
      url          = {https://publications.rwth-aachen.de/record/991096},
}