Particle Size Enlargement Through Wet Granulation on the QbCon 1

Tölle, Stefan Ruben; Delvos, Alana; Breitkreutz, Jörg; Dörschel, Lorenz Matthias; Vallery, Heike; Stemmler, Sebastian; Klinken-Uth, Stefan

doi:10.18154/RWTH-2026-01122

Particle Size Enlargement Through Wet Granulation on the QbCon 1

Tölle, Stefan Ruben^RWTH* ; Dörschel, Lorenz Matthias^RWTH* ; Klinken-Uth, Stefan ; Delvos, Alana ; Breitkreutz, Jörg ; Vallery, Heike^RWTH* ; Stemmler, Sebastian^RWTH*

2026

Online
DOI: 10.18154/RWTH-2026-01122
URL: https://publications.rwth-aachen.de/record/1026996/files/Particle-Size-QbCon.zip

Einrichtungen

Lehrstuhl und Institut für Regelungstechnik (416610)

Projekte

DFG project G:(GEPRIS)504702251 - Modellbasierte Qualitätsregelung in der kontinuierlichen Produktion pharmazeutischer Granulate und Tabletten (QC4CM) (504702251) (504702251)

Inhaltliche Beschreibung (Schlagwörter)
wet granulation (frei) ; sparse identification of nonlinear dynamics (frei) ; population balance models (frei) ; continuous manufacturing (frei) ; pharmaceutical systems (frei)

Kurzfassung
This dataset contains residence time and particle size measurements from twin-screw wet granulation experiments conducted on the QbCon 1 (L.B. Bohle Maschinen+Verfahren, Ennigerloh, Germany). Particle size distributions were measured using a Parsum Probe IPP 70-S (Parsum GmbH, Chemnitz, Germany). The data contains particle size measurements for various amounts of granulation liquid. Additionally, a population balance model, which predicts the particle size distribution, is included.

OpenAccess:
ZIP
(additional files)