OXYTRAIN
Harnessing the power of enzymatic oxygen activation
| Coordinator | DSM Food Specialties ; RWTH Aachen University ; SESAM-BIOTECH GMBH ; SANKO TEKSTIL ISLETMELERI SANAYI VETICARET ANONIM SIRKETI ; Università degli Studi di Pavia ; TECHNISCHE UNIVERSITAET GRAZ ; NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET ; University of York ; University of Groningen ; WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER |
| Grant period | 2017-01-01 - 2021-03-31 |
| Funding body | European Union |
| Call number | H2020-MSCA-ITN-2016 |
| Grant number | 722390 |
| Identifier | G:(EU-Grant)722390 |
Note: For the selective and effective incorporation of oxygen into biological molecules (oxygenation reaction), several enzyme types have evolved in nature. They catalyse crucial reactions in various metabolic routes. The chemistry feasible with these biocatalysts is unrivalled when compared with conventional chemical methods. Therefore, these oxygenating enzymes are very promising tools in biotechnological approaches. However, when compared with other enzyme classes, such as hydrolases, oxygenases are still in their infancy considering their biotechnological potential. To fully exploit the catalytic power of oxygenases, several hurdles have to be taken for which a higher level of knowledge on these enzymes is needed while also technical aspects have to be solved.
The European Training Network (ETN) OXYTRAIN is a joint academic/non-academic training initiative supporting the convergence of biochemistry, enzyme engineering and biotechnology. The consortium's mutual goal is developing a new generation of innovative and entrepreneurial early stage researchers (ESRs) to satisfy the need for knowledge and skills to produce and apply oxidative enzymes. This will be achieved by setting up a network and intersectoral programme in which multiple disciplines will be integrated and exploited. By bringing together 7 academic beneficiaries that are experts in the field of individual oxygenase groups, the network will provide perfect conditions for cross-fertilization of knowledge, while the 3 industrial beneficiaries and 5 partner organisations will add to the consortium by translating the generated knowledge into real industrial applications, such as textiles, pharmaceuticals and biorefineries.
Recent Publications
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Dissertation / PhD Thesis
Srdic, M.RWTH* ; Schwaneberg, U. (Thesis advisor)RWTH* ; Elling, L. (Thesis advisor)RWTH*
Development and application of the human cytochrome P450 monooxygenase 3A4 for preparative scale biocatalysis of valuable pharmaceutical compounds
Aachen : RWTH Aachen University 1 Online-Ressource : Illustrationen (2024) [10.18154/RWTH-2025-02940]2024 = Dissertation, RWTH Aachen University, 2024
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Dissertation / PhD Thesis
de Almeida Santos, G.RWTH* ; Schwaneberg, U. (Thesis advisor)RWTH* ; Blank, L. M. (Thesis advisor)RWTH*
Engineering of heme-dependent monooxygenases towards heterocycle conversion
Aachen 1 Online-Ressource (vi, 100 Seiten) : Illustrationen, Diagramme (2020) [10.18154/RWTH-2020-10487]2020 = Dissertation, RWTH Aachen University, 2020
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